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Incretin & Amylin Analogues

Tirzepatide

Tirzepatide is a synthetic lipidated peptide. Supplied as a lyophilised powder in a sealed vial for laboratory research. Available in 10 mg, 20 mg and 40 mg presentations.

In stock
Concentration
10 mg vial£60.00

£6.00 per mg

≥99% purity (HPLC) · Independent third-party testing by PeptideVerify · COA Library

Order before 3pm for same-day dispatch.

Cut-off 3pm, Mon–Sat

Free next-day tracked delivery on every order · Royal Mail Tracked 24

10 mg · £60.00 · £6.00/mg

At a glance

Research area
Incretin & Amylin Analogues · Explore the research area
Presentations
10 mg, 20 mg and 40 mg
Form
Lyophilised powder in a sealed vial
Purity
≥99% (HPLC)
CAS number
2023788-19-2
Molecular formula
C225H348N48O68
Molecular weight
4813.45 g/mol
Dispatch
Order by 3pm Mon–Sat for same-day dispatch

About Tirzepatide

Tirzepatide is a synthetic lipidated peptide: a linear chain of thirty-nine amino acid residues conjugated to a C20 dicarboxylic acid. Its sequence is based on that of GIP, and by receptor class it is a GIP and GLP-1 receptor agonist peptide.

The catalogue lists CAS number 2023788-19-2, the molecular formula C225H348N48O68 and a molecular weight of 4813.45 g/mol, covering the peptide chain and the diacid together. The diacid gives the molecule an amphiphilic character, a long hydrocarbon chain on an otherwise polar peptide, so it is strongly retained in reversed-phase HPLC. Identity is confirmed by electrospray mass spectrometry, deconvoluted from multiply charged ions to a neutral mass for comparison with the expected value. Each presentation is supplied as a lyophilised powder in a sealed vial.

Further reading

Tirzepatide structure and analytical profile

In one-letter code the chain reads Y-Aib-EGTFTSDYSI-Aib-LDKIAQKAFVQWLIAGGPSSGAPPPS-NH2: thirty-nine residues from an N-terminal tyrosine with a free amine to a C-terminal serine amide, Ser39-NH2. The amide closes the chain without a free carboxylic acid, which leaves the diacid's terminal carboxyl and the acidic side chains as the molecule's acid groups.

Positions 2 and 13 carry α-aminoisobutyric acid (Aib), an α,α-disubstituted residue with two methyl groups on its α-carbon and no stereocentre. Each Aib is 14 Da heavier than alanine, so tandem mass spectrometry locates both from the fragment ions. The single tryptophan, at position 25, and the tyrosines give the chain usable ultraviolet absorbance near 280 nm.

The side chain of lysine 20 is acylated with a C20 fatty diacid, joined through a γ-glutamic acid unit and two OEG spacers, short ethylene-glycol-based amino acids. From the lysine outward the group runs spacer, spacer, γ-glutamic acid and then the twenty-carbon chain, which ends in a free carboxylic acid. The molecular formula C225H348N48O68 counts the chain, both spacers, the linker and the diacid as one molecule.

The hydrocarbon segment is what dominates the chromatography: tirzepatide is retained strongly in reversed-phase HPLC, and a chain without its diacid, or with the group on a different lysine, elutes elsewhere and weighs differently. That gives retention time and mass two independent checks on the attachment.

Of the chain's two lysines, Lys16 keeps a free side-chain amine and Lys20 carries the lipid group, so the position of the diacid is fixed in the sequence and confirmed by the fragment ions around residue 20.

The monoisotopic mass is 4810.52 Da and the average molecular weight 4813.45 g/mol. The [M+H]+ ion is calculated at m/z 4811.53, while electrospray shows mainly multiply charged ions, such as [M+3H]3+ near m/z 1604.51 and [M+4H]4+ near m/z 1203.64, which are deconvoluted to one neutral mass. Reversed-phase HPLC reports purity as the main peak's share of total peak area, and LC-MS confirms the mass.

The glutamines at positions 19 and 24 are the residues most able to deamidate, a shift of +0.98 Da that high-resolution mass spectrometry resolves from the main ion.

The material is a white to off-white lyophilised solid in a sealed vial. The sealed vial is stored at 2–8 °C short term, or at −20 °C and below for long-term storage, protected from light and away from repeated freeze-thaw cycles.

Buying Tirzepatide in the UK

Order Tirzepatide directly from British Peptide Labs, a UK-registered company, as a sealed vial in 10 mg, 20 mg and 40 mg presentations, from £60. Every size is listed below with its vial price and its price per mg, so the presentations compare at a glance.

Tirzepatide price (UK)
PresentationPrice£/mg
Tirzepatide 10 mg£60.00£6.00
Tirzepatide 20 mgOut of stock£90.00£4.50
Tirzepatide 40 mgBest value£120.00£3.00

Choose a presentation in the buy box, add it to your basket and check out. Orders placed before 3pm Mon–Sat are packed the same working day and handed to Royal Mail Tracked 24, and your tracking number is emailed as soon as the parcel leaves us. Larger orders are welcome: add as many vials as your laboratory needs in a single basket.

For what other UK suppliers charge, see our UK price per mg data, updated every month.

Product information

CAS number
2023788-19-2
Molecular formula
C225H348N48O68
Molecular weight
4813.45 g/mol
Appearance
White to off-white lyophilised powder
Purity
≥99% (HPLC)
Net content
10 mg, 20 mg or 40 mg per vial
Storage (sealed vial)
Store at 2–8 °C short term, or at −20 °C and below for long-term storage. Protect from light and avoid repeated freeze-thaw cycles
PubChem CID
166567236
Research use
For laboratory research use only. Not for human or veterinary use.

Tirzepatide is a synthetic lipidated peptide. Supplied as a lyophilised powder in a sealed vial for laboratory research. Available in 10 mg, 20 mg and 40 mg presentations. Store the sealed vial at 2–8 °C for short-term storage, or at −20 °C and below for long term. Protect from light and avoid repeated freeze-thaw cycles. For research use only. Not for human or veterinary use. Sold strictly for in-vitro laboratory research; not for diagnosis or treatment.

Packing
Each sealed vial travels in protective packing.
Dispatch
Orders placed before 3pm Mon–Sat leave the same day.
Delivery
Next-day tracked delivery with Royal Mail Tracked 24.
Tracking
Your tracking number is emailed as soon as the order is dispatched.
Delivery cost
Delivery is free on every order.
Shipping details

Questions about Tirzepatide

Tirzepatide is a synthetic lipidated peptide. It is supplied in a sealed vial as a white to off-white lyophilised powder, in 10 mg, 20 mg and 40 mg presentations.

Read the Learn article

Y-Aib-EGTFTSDYSI-Aib-LDKIAQKAFVQWLIAGGPSSGAPPPS-NH2. Aib is written out because α-aminoisobutyric acid has no one-letter code, the -NH2 marks the C-terminal serine amide, and the lysine at position 20 carries the fatty diacid side chain.

4810.52 Da, against an average molecular weight of 4813.45 g/mol. The [M+H]+ ion is calculated at m/z 4811.53; in electrospray LC-MS the [M+3H]3+ ion near m/z 1604.51 and the [M+4H]4+ ion near m/z 1203.64 are the ones usually read.

Thirty-nine. Thirty-seven are coded amino acids and two, at positions 2 and 13, are α-aminoisobutyric acid. The chain runs from a free N-terminal tyrosine to a C-terminal serine amide.

On the side-chain amine of lysine 20. A C20 fatty diacid is joined there through a γ-glutamic acid unit and two OEG spacers. The formula C225H348N48O68 includes that whole side chain.

2023788-19-2. The same record gives the molecular formula C225H348N48O68 and a molecular weight of 4813.45 g/mol, and PubChem lists the compound as CID 166567236.

Because of the C20 diacid on lysine 20. The long hydrocarbon chain binds strongly to the non-polar stationary phase, so the peptide needs a higher organic fraction in the mobile phase to elute than a chain of the same length without the diacid.

A white to off-white lyophilised powder, one sealed vial per presentation, with the net peptide content printed on the label. The vial is kept sealed at 2–8 °C short term, or at −20 °C and below for long-term storage, away from light.

Order Tirzepatide directly from British Peptide Labs, a UK-registered company. It is supplied in sealed 10 mg, 20 mg and 40 mg vials, from £3.00 per mg on the 40 mg vial. The 10 mg and 40 mg vials are in stock. Every vial is ≥99% purity (HPLC), with independent third-party testing by PeptideVerify. Orders placed before 3pm Mon–Sat leave the same day by Royal Mail Tracked 24 for next-day tracked delivery.

Tirzepatide comes in sealed vials: 10 mg at £60.00 (£6.00 per mg), 20 mg at £90.00 (£4.50 per mg) and 40 mg at £120.00 (£3.00 per mg). Delivery is free on every order.

Tirzepatide is catalogued in the Incretin & Amylin Analogues research area, where compounds are grouped by molecular class. The research area page lists each of them with its identifiers.

Incretin & Amylin Analogues research area

Tirzepatide has independent third-party testing by PeptideVerify: reversed-phase HPLC measures purity, at ≥99% (HPLC), and LC-MS confirms identity against the expected mass.

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