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NAD+
In stock · 500 mg
£70.00
£0.14/mg
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Mitochondrial Compounds
SS-31
Also written elamipretide · SS31
SS-31 is a synthetic tetrapeptide. Supplied as a lyophilised powder in a sealed vial for laboratory research. Available in a 50 mg presentation.
Out of stock
50 mg vial£150.00
£3.00 per mg
≥99% purity (HPLC) · Independent third-party testing by PeptideVerify · COA Library
Free next-day tracked delivery on every order · Royal Mail Tracked 24
50 mg · £150.00 · £3.00/mg
At a glance
- Research area
- Mitochondrial Compounds · Explore the research area
- Presentations
- 50 mg
- Form
- Lyophilised powder in a sealed vial
- Purity
- ≥99% (HPLC)
- CAS number
- 736992-21-5
- Molecular formula
- C32H49N9O5
- Molecular weight
- 639.79 g/mol
- Residues
- 4
- Monoisotopic mass
- 639.3857 Da
- Dispatch
- Order by 3pm Mon–Sat for same-day dispatch
About SS-31
SS-31 is a synthetic tetrapeptide, H-D-Arg-Dmt-Lys-Phe-NH2, of the aromatic-cationic class: basic and aromatic residues alternate along the chain. Dmt is 2′,6′-dimethyltyrosine, a tyrosine with two methyl groups on its aromatic ring; the N-terminal arginine has the D-configuration, and the C-terminal phenylalanine ends in an amide. Its three basic groups are the arginine guanidine, the lysine side-chain amine and the free N-terminal amine, and the amide terminus carries no negative charge, so the molecule is strongly cationic at neutral pH.
The catalogue lists CAS number 736992-21-5, the molecular formula C32H49N9O5 and a molecular weight of 639.79 g/mol. Short, highly charged peptides like this are retained weakly in reversed-phase HPLC without an ion-pairing agent, and they give intense multiply charged ions in electrospray mass spectrometry. Each presentation is supplied as a lyophilised powder in a sealed vial.
Identifiers
- PubChem CID 11764719
Further reading
SS-31 structure and analytical profile
The four residues are D-Arg1, Dmt2, Lys3 and Phe4, written compactly as r[Dmt]KF-NH2, where the lower-case r marks D-arginine. Dmt, 2′,6′-dimethyl-L-tyrosine, is a tyrosine with one methyl group on each side of the ring carbon that joins the side chain; as a free amino acid it has the formula C11H15NO3 and a molecular weight of 209.24 g/mol.
The chain alternates charge and ring: a basic arginine, an aromatic Dmt, a basic lysine and an aromatic phenylalanine. D-Arg1 is the one D-configured residue, and a diastereomer with L-arginine in its place has the same mass, so chromatography or chiral amino acid analysis, rather than mass spectrometry, confirms the configuration.
The two methyl groups of Dmt sit on the ring carbons either side of the side-chain attachment, which makes Dmt 28 Da heavier than tyrosine and more hydrophobic.
The N-terminal D-arginine keeps a free amine, and the C-terminal phenylalanine ends in an amide, -NH2, so the chain has no free carboxylic acid and no acidic side chain. Its positive groups are the arginine guanidine, the lysine side-chain amine and the N-terminal amine.
The calculated net charge near pH 7 is about +3, a high charge for a four-residue chain. That charge density explains its weak retention in reversed-phase HPLC without an ion-pairing agent, and its readiness to form doubly and triply protonated ions in electrospray.
Without an acidic group anywhere in the chain, the peptide stays cationic across the pH range of a typical reversed-phase separation.
The monoisotopic mass is 639.3857 Da, so the [M+H]+ ion is expected at m/z 640.3929, the [M+2H]2+ ion at m/z 320.7001 and the [M+3H]3+ ion at m/z 214.1358. The formula C32H49N9O5 and the 639.79 g/mol molecular weight refer to the free peptide; an acetate or trifluoroacetate salt weighs more per mole.
Tandem mass spectrometry reads the four residues in order from the fragment ions, and the Dmt residue, 28 Da above tyrosine, is easy to place among them.
Reversed-phase HPLC with an ion-pairing mobile phase, read around 214 nm or where the Dmt and phenyl rings absorb, gives purity as the main peak's share of total peak area. The material is a white to off-white lyophilised solid in a sealed vial. The sealed vial is stored at 2–8 °C short term, or at −20 °C and below for long-term storage, protected from light and away from repeated freeze-thaw cycles.
SS-31 and MOTS-c: structure notes
| Property | SS-31 | MOTS-c |
|---|---|---|
| Residues | 4 | 16 |
| Molecular formula | C32H49N9O5 | C101H152N28O22S2 |
| Average molecular weight | 639.79 g/mol | 2174.60 g/mol |
| Monoisotopic mass | 639.3857 Da | 2173.1077 Da |
| Net charge near pH 7 | +3.0 | +3.0 |
| Disulfide bridges | 0 | 0 |
SS-31 is a four-residue chain with a D-arginine, a dimethyltyrosine and an amide end, at 639.79 g/mol. MOTS-c is a linear sixteen-residue chain of coded amino acids with free termini, at 2174.6 g/mol; both are strongly cationic near pH 7.
View MOTS-cBuying SS-31 in the UK
Order SS-31 directly from British Peptide Labs, a UK-registered company, as a sealed vial in 50 mg presentation. Every size is listed below with its vial price and its price per mg, so the presentations compare at a glance.
| Presentation | Price | £/mg |
|---|---|---|
| SS-31 50 mgOut of stock | £150.00 | £3.00 |
Choose a presentation in the buy box, add it to your basket and check out. Orders placed before 3pm Mon–Sat are packed the same working day and handed to Royal Mail Tracked 24, and your tracking number is emailed as soon as the parcel leaves us. Larger orders are welcome: add as many vials as your laboratory needs in a single basket.
For what other UK suppliers charge, see our UK price per mg data, updated every month.
Product information
- Synonym
- elamipretide, SS31
- CAS number
- 736992-21-5
- Molecular formula
- C32H49N9O5
- Molecular weight
- 639.79 g/mol
- Sequence
- D-Arg-Dmt-Lys-Phe-NH2
- Appearance
- White to off-white lyophilised powder
- Purity
- ≥99% (HPLC)
- Net content
- 50 mg per vial
- Storage (sealed vial)
- Store at 2–8 °C short term, or at −20 °C and below for long-term storage. Protect from light and avoid repeated freeze-thaw cycles
- Residues
- 4
- One-letter sequence
- r[Dmt]KF-NH2
- Monoisotopic mass
- 639.3857 Da
- Expected [M+H]+
- m/z 640.3929
- Net charge near pH 7
- +3.0
- PubChem CID
- 11764719
- Research use
- For laboratory research use only. Not for human or veterinary use.
SS-31 is a synthetic tetrapeptide. Supplied as a lyophilised powder in a sealed vial for laboratory research. Available in a 50 mg presentation. Store the sealed vial at 2–8 °C for short-term storage, or at −20 °C and below for long term. Protect from light and avoid repeated freeze-thaw cycles. For research use only. Not for human or veterinary use. Sold strictly for in-vitro laboratory research; not for diagnosis or treatment.
- Packing
- Each sealed vial travels in protective packing.
- Dispatch
- Orders placed before 3pm Mon–Sat leave the same day.
- Delivery
- Next-day tracked delivery with Royal Mail Tracked 24.
- Tracking
- Your tracking number is emailed as soon as the order is dispatched.
- Delivery cost
- Delivery is free on every order.
Questions about SS-31
SS-31 is a synthetic tetrapeptide. It is supplied in a sealed vial as a white to off-white lyophilised powder, in a 50 mg presentation.
Read the Learn articleYes. SS31 is another spelling of SS-31: the tetrapeptide D-Arg-Dmt-Lys-Phe-NH2, catalogued under CAS number 736992-21-5 with the formula C32H49N9O5.
639.3857 Da. The [M+H]+ ion is expected at m/z 640.3929 and the [M+2H]2+ ion at m/z 320.7001, against an average molecular weight of 639.79 g/mol for the free peptide.
That aromatic and basic residues alternate along the chain: D-arginine, dimethyltyrosine, lysine and phenylalanine. The result is a short peptide with two ring systems and three positive charges. Dmt, 2′,6′-dimethyltyrosine, carries two extra methyl groups on its ring, 28 Da more than tyrosine.
About +3, from the arginine guanidine, the lysine side-chain amine and the free N-terminal amine. The amidated C-terminus and the lack of acidic side chains leave no negative charge to offset them.
736992-21-5, with the molecular formula C32H49N9O5 and a molecular weight of 639.79 g/mol. PubChem lists the compound as CID 11764719. The formula and molecular weight refer to the free peptide; a salt form weighs more per mole.
The N-terminal arginine. Dmt, lysine and phenylalanine are L-residues, and a diastereomer with L-arginine has the same mass, so HPLC retention confirms the configuration.
Because a four-residue chain with three positive charges is very polar and is retained only weakly on a reversed-phase column. An ion-pairing agent in the mobile phase pairs with those charges and gives a well-retained, quantifiable main peak.
Order SS-31 directly from British Peptide Labs, a UK-registered company. It is supplied in a sealed 50 mg vial at £150.00 (£3.00 per mg). Every vial is ≥99% purity (HPLC), with independent third-party testing by PeptideVerify. Orders placed before 3pm Mon–Sat leave the same day by Royal Mail Tracked 24 for next-day tracked delivery.
SS-31 comes in one sealed vial: 50 mg at £150.00 (£3.00 per mg). Delivery is free on every order.
SS-31 is catalogued in the Mitochondrial Compounds research area, where compounds are grouped by molecular class. The research area page lists each of them with its identifiers.
Mitochondrial Compounds research areaSS-31 has independent third-party testing by PeptideVerify: reversed-phase HPLC measures purity, at ≥99% (HPLC), and LC-MS confirms identity against the expected mass.
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