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In stock · 500 mg
£70.00
£0.14/mg
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Mitochondrial Compounds
MOTS-c
Also written MOTSc · MOTS c
MOTS-c is a synthetic peptide of sixteen amino acid residues. Supplied as a lyophilised powder in a sealed vial for laboratory research. Available in a 40 mg presentation.
In stock
40 mg vial£80.00
£2.00 per mg
≥99% purity (HPLC) · Independent third-party testing by PeptideVerify · COA Library
Order before 3pm for same-day dispatch.
Cut-off 3pm, Mon–Sat
Free next-day tracked delivery on every order · Royal Mail Tracked 24
40 mg · £80.00 · £2.00/mg
At a glance
- Research area
- Mitochondrial Compounds · Explore the research area
- Presentations
- 40 mg
- Form
- Lyophilised powder in a sealed vial
- Purity
- ≥99% (HPLC)
- CAS number
- 1627580-64-6
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.6 g/mol
- Residues
- 16
- Monoisotopic mass
- 2173.1077 Da
- Dispatch
- Order by 3pm Mon–Sat for same-day dispatch
About MOTS-c
MOTS-c is a synthetic linear peptide of sixteen amino acid residues, H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH, and a mitochondria-derived peptide. It is built only from standard amino acids, with a free amine at the N-terminus, a free carboxylic acid at the C-terminus and no side-chain modification. Four residues are basic (three arginines and a lysine) and four aromatic (a tryptophan, two tyrosines and a phenylalanine).
The catalogue lists CAS number 1627580-64-6, the molecular formula C101H152N28O22S2 and a molecular weight of 2174.6 g/mol; the two sulfur atoms come from its two methionines. Those methionines are the likeliest sites of oxidation, each adding 16 Da, so mass spectrometry looks for them alongside the expected mass, while the tryptophan and tyrosines give good ultraviolet absorbance at 280 nm for HPLC. Each presentation is supplied as a lyophilised powder in a sealed vial.
Identifiers
- PubChem CID 146675088
Further reading
MOTS-c structure and analytical profile
In one-letter code the chain reads MRWQEMGYIFYPRKLR, from Met1 to Arg16. All sixteen residues are coded L-amino acids apart from glycine at position 7. Methionine sits at positions 1 and 6, the aromatic residues at 3 (Trp), 8 and 11 (Tyr) and 10 (Phe), and the basic residues at 2, 13 and 16 (Arg) and 14 (Lys); Gln4, Glu5, Ile9, Pro12 and Leu15 complete the chain.
The aromatic block in the middle of the chain, Tyr-Ile-Phe-Tyr, and the arginine-rich C-terminal end give MOTS-c a clear two-part character: a hydrophobic core flanked by charged residues. That mix of aromatic and basic side chains is what makes the peptide easy to see by ultraviolet detection and easy to ionise in positive-mode electrospray.
Its three arginines carry guanidine side chains, the most strongly basic group among the coded amino acids, which keeps them protonated across the whole pH range of a reversed-phase separation.
Both ends are unmodified: Met1 keeps a free amine and Arg16 a free carboxylic acid, with no acetyl cap and no amide. Against four basic side chains and the N-terminal amine, the chain has only one acidic side chain, Glu5, plus the C-terminal carboxyl.
The calculated net charge near pH 7 is about +3, so MOTS-c is a cationic peptide. Its two methionines are the main sites of oxidation: each can form the sulfoxide, adding 16 Da per site, which is why a mass spectrum is read for +16 and +32 Da companions to the main ion.
The C-terminal Arg16 keeps its free carboxyl, so the end of the chain carries both a positive side chain and a negative terminal charge.
The monoisotopic mass is 2173.1077 Da. The [M+H]+ ion is expected at m/z 2174.1150, though electrospray favours the multiply charged forms, [M+2H]2+ at m/z 1087.5612 and [M+3H]3+ at m/z 725.3765. Reversed-phase HPLC with detection at 280 nm, where the tryptophan and tyrosines absorb, or around 214 nm gives purity as the main peak's share of total peak area.
Tandem mass spectrometry confirms the order of the sixteen residues while the two methionines are read for oxidation, so one LC-MS run checks sequence, mass and the main related substances together.
The material is a white to off-white lyophilised solid in a sealed vial. The sealed vial is stored at 2–8 °C short term, or at −20 °C and below for long-term storage, protected from light and away from repeated freeze-thaw cycles.
MOTS-c and SS-31: structure notes
| Property | MOTS-c | SS-31 |
|---|---|---|
| Residues | 16 | 4 |
| Molecular formula | C101H152N28O22S2 | C32H49N9O5 |
| Average molecular weight | 2174.60 g/mol | 639.79 g/mol |
| Monoisotopic mass | 2173.1077 Da | 639.3857 Da |
| Net charge near pH 7 | +3.0 | +3.0 |
| Disulfide bridges | 0 | 0 |
MOTS-c is a linear sixteen-residue chain of coded amino acids with free termini, at 2174.6 g/mol. SS-31 is a four-residue chain with a D-arginine, a dimethyltyrosine and an amide end, at 639.79 g/mol; both are strongly cationic near pH 7.
View SS-31Buying MOTS-c in the UK
Order MOTS-c directly from British Peptide Labs, a UK-registered company, as a sealed vial in 40 mg presentation, from £80. Every size is listed below with its vial price and its price per mg, so the presentations compare at a glance.
| Presentation | Price | £/mg |
|---|---|---|
| MOTS-c 40 mg | £80.00 | £2.00 |
Priced at £2.00/mg, below the UK median of £2.37/mg across 15 suppliers in the October 2026 UK Research Peptide Price Index.
Choose a presentation in the buy box, add it to your basket and check out. Orders placed before 3pm Mon–Sat are packed the same working day and handed to Royal Mail Tracked 24, and your tracking number is emailed as soon as the parcel leaves us. Larger orders are welcome: add as many vials as your laboratory needs in a single basket.
For what other UK suppliers charge, see our UK price per mg data, updated every month.
Product information
- Synonym
- MOTSc, MOTS c
- CAS number
- 1627580-64-6
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.6 g/mol
- Sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Appearance
- White to off-white lyophilised powder
- Purity
- ≥99% (HPLC)
- Net content
- 40 mg per vial
- Storage (sealed vial)
- Store at 2–8 °C short term, or at −20 °C and below for long-term storage. Protect from light and avoid repeated freeze-thaw cycles
- Residues
- 16
- One-letter sequence
- MRWQEMGYIFYPRKLR
- Monoisotopic mass
- 2173.1077 Da
- Expected [M+H]+
- m/z 2174.1150
- Net charge near pH 7
- +3.0
- PubChem CID
- 146675088
- Research use
- For laboratory research use only. Not for human or veterinary use.
MOTS-c is a synthetic peptide of sixteen amino acid residues. Supplied as a lyophilised powder in a sealed vial for laboratory research. Available in a 40 mg presentation. Store the sealed vial at 2–8 °C for short-term storage, or at −20 °C and below for long term. Protect from light and avoid repeated freeze-thaw cycles. For research use only. Not for human or veterinary use. Sold strictly for in-vitro laboratory research; not for diagnosis or treatment.
- Packing
- Each sealed vial travels in protective packing.
- Dispatch
- Orders placed before 3pm Mon–Sat leave the same day.
- Delivery
- Next-day tracked delivery with Royal Mail Tracked 24.
- Tracking
- Your tracking number is emailed as soon as the order is dispatched.
- Delivery cost
- Delivery is free on every order.
Questions about MOTS-c
MOTS-c is a synthetic peptide of sixteen amino acid residues. It is supplied in a sealed vial as a white to off-white lyophilised powder, in a 40 mg presentation.
Read the Learn articleYes. MOTSc and MOTS c are other spellings of MOTS-c: the same sixteen-residue peptide, MRWQEMGYIFYPRKLR, catalogued under CAS number 1627580-64-6.
2173.1077 Da, against an average molecular weight of 2174.6 g/mol. The [M+H]+ ion is expected at m/z 2174.1150, and in electrospray the [M+2H]2+ ion at m/z 1087.5612 and the [M+3H]3+ ion at m/z 725.3765 are the strongest.
MRWQEMGYIFYPRKLR, from the N-terminal methionine to the C-terminal arginine. Both termini are free, so the full form is H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH.
About +3. Three arginines, a lysine and the N-terminal amine outweigh the single glutamic acid and the C-terminal carboxyl, which makes MOTS-c a cationic peptide.
The two methionines, at positions 1 and 6. Each can form a sulfoxide, 16 Da heavier, so the mass spectrum is checked for +16 and +32 Da companions to the main ion.
1627580-64-6, with the molecular formula C101H152N28O22S2 and a molecular weight of 2174.6 g/mol. PubChem lists the compound as CID 146675088. The two sulfur atoms in the formula are its two methionines.
A white to off-white lyophilised powder in a sealed vial, with the net peptide content on the label. The sealed vial is kept at 2–8 °C short term, or at −20 °C and below for long-term storage, away from light.
Order MOTS-c directly from British Peptide Labs, a UK-registered company. It is supplied in a sealed 40 mg vial at £80.00 (£2.00 per mg). The 40 mg vial is in stock. Every vial is ≥99% purity (HPLC), with independent third-party testing by PeptideVerify. Orders placed before 3pm Mon–Sat leave the same day by Royal Mail Tracked 24 for next-day tracked delivery.
MOTS-c comes in one sealed vial: 40 mg at £80.00 (£2.00 per mg). Delivery is free on every order.
MOTS-c is catalogued in the Mitochondrial Compounds research area, where compounds are grouped by molecular class. The research area page lists each of them with its identifiers.
Mitochondrial Compounds research areaMOTS-c has independent third-party testing by PeptideVerify: reversed-phase HPLC measures purity, at ≥99% (HPLC), and LC-MS confirms identity against the expected mass.
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