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GHRH, GHS-R & IGF-1 Analogues

Tesamorelin

Tesamorelin is a synthetic analogue of growth-hormone-releasing factor, a peptide of forty-four amino acid residues bearing an N-terminal trans-3-hexenoyl group. Supplied as a lyophilised powder in a sealed vial for laboratory research. Available in a 10 mg presentation.

Out of stock
10 mg vial£85.00

£8.50 per mg

≥99% purity (HPLC) · Independent third-party testing by PeptideVerify · COA Library

Free next-day tracked delivery on every order · Royal Mail Tracked 24

10 mg · £85.00 · £8.50/mg

At a glance

Research area
GHRH, GHS-R & IGF-1 Analogues · Explore the research area
Presentations
10 mg
Form
Lyophilised powder in a sealed vial
Purity
≥99% (HPLC)
CAS number
218949-48-5
Molecular formula
C221H366N72O67S
Molecular weight
5135.9 g/mol
Dispatch
Order by 3pm Mon–Sat for same-day dispatch

About Tesamorelin

Tesamorelin is a synthetic analogue of GHRH: a peptide of forty-four amino acid residues with the sequence of GHRH(1–44), carrying an N-terminal trans-3-hexenoyl group. That acyl group is a six-carbon chain with one carbon–carbon double bond in the E (trans) configuration, attached to the N-terminal tyrosine.

The catalogue lists CAS number 218949-48-5, the molecular formula C221H366N72O67S and a molecular weight of 5135.9 g/mol. The single sulfur atom in the formula comes from the chain's one methionine; there is no cysteine and so no disulfide bridge. At this mass, identity is confirmed by electrospray mass spectrometry, deconvoluted from multiply charged ions to a neutral mass, and reversed-phase HPLC gives the chromatographic profile, in which the methionine sulfoxide, 16 Da heavier, is a typical related substance. Each presentation is supplied as a lyophilised powder in a sealed vial.

Identifiers

  • PubChem CID 16137828

Further reading

Tesamorelin structure and analytical profile

Tesamorelin carries the full forty-four-residue sequence of GHRH(1–44), all coded amino acids, from an N-terminal tyrosine to residue 44. What sets it apart is the cap on that tyrosine: its α-amine is acylated with a trans-3-hexenoyl group, CH3-CH2-CH=CH-CH2-CO-, so the chain starts with an amide instead of a free amine.

The acyl group is six carbons long with one carbon–carbon double bond between C3 and C4 in the E (trans) configuration. It adds C6H8O, about 96.06 Da, to the formula of the unacylated chain, and its short hydrocarbon tail lengthens the peptide's retention in reversed-phase HPLC slightly.

Because the acyl cap takes the place of a free N-terminal amine, the chain's positive charges come only from its basic side chains, and Edman sequencing cannot start at the N-terminus; tandem mass spectrometry confirms the sequence instead.

The formula C221H366N72O67S has one sulfur atom, from the chain's single methionine. With no cysteine there is no disulfide bridge to form or check, which keeps the structure a single linear chain from end to end.

That methionine is the residue most prone to oxidation. Its sulfoxide adds one oxygen atom, 16 Da, and elutes slightly earlier than the parent peptide in reversed-phase HPLC, so it is the related substance an analysis looks for first, alongside shorter chains from incomplete synthesis.

Deletion sequences, chains missing one residue, are the other typical related substances of a synthetic chain this long. Each sits one residue mass below the full chain, so a deconvoluted mass spectrum separates them from the main component, while HPLC resolves most of them as small peaks near the main one.

At 5135.9 g/mol, tesamorelin appears in electrospray mass spectrometry as a series of multiply charged ions, which are deconvoluted to a single neutral mass and matched to the value calculated from the formula. Reversed-phase HPLC gives purity as the main peak's share of total peak area.

At this mass the monoisotopic peak is a minor part of the isotope envelope, so the deconvoluted spectrum is read against the average molecular weight of 5135.9 g/mol.

The material is a white to off-white lyophilised solid in a sealed vial. The sealed vial is stored at 2–8 °C short term, or at −20 °C and below for long-term storage, protected from light and away from repeated freeze-thaw cycles.

Buying Tesamorelin in the UK

Order Tesamorelin directly from British Peptide Labs, a UK-registered company, as a sealed vial in 10 mg presentation. Every size is listed below with its vial price and its price per mg, so the presentations compare at a glance.

Tesamorelin price (UK)
PresentationPrice£/mg
Tesamorelin 10 mgOut of stock£85.00£8.50

Choose a presentation in the buy box, add it to your basket and check out. Orders placed before 3pm Mon–Sat are packed the same working day and handed to Royal Mail Tracked 24, and your tracking number is emailed as soon as the parcel leaves us. Larger orders are welcome: add as many vials as your laboratory needs in a single basket.

For what other UK suppliers charge, see our UK price per mg data, updated every month.

Product information

CAS number
218949-48-5
Molecular formula
C221H366N72O67S
Molecular weight
5135.9 g/mol
Appearance
White to off-white lyophilised powder
Purity
≥99% (HPLC)
Net content
10 mg per vial
Storage (sealed vial)
Store at 2–8 °C short term, or at −20 °C and below for long-term storage. Protect from light and avoid repeated freeze-thaw cycles
PubChem CID
16137828
Research use
For laboratory research use only. Not for human or veterinary use.

Tesamorelin is a synthetic analogue of growth-hormone-releasing factor, a peptide of forty-four amino acid residues bearing an N-terminal trans-3-hexenoyl group. Supplied as a lyophilised powder in a sealed vial for laboratory research. Available in a 10 mg presentation. Store the sealed vial at 2–8 °C for short-term storage, or at −20 °C and below for long term. Protect from light and avoid repeated freeze-thaw cycles. For research use only. Not for human or veterinary use. Sold strictly for in-vitro laboratory research; not for diagnosis or treatment.

Packing
Each sealed vial travels in protective packing.
Dispatch
Orders placed before 3pm Mon–Sat leave the same day.
Delivery
Next-day tracked delivery with Royal Mail Tracked 24.
Tracking
Your tracking number is emailed as soon as the order is dispatched.
Delivery cost
Delivery is free on every order.
Shipping details

Questions about Tesamorelin

Tesamorelin is a synthetic analogue of growth-hormone-releasing factor, a peptide of forty-four amino acid residues bearing an N-terminal trans-3-hexenoyl group. It is supplied in a sealed vial as a white to off-white lyophilised powder, in a 10 mg presentation.

Read the Learn article

A six-carbon acyl group, CH3-CH2-CH=CH-CH2-CO-, with one carbon–carbon double bond in the E (trans) configuration. It is attached to the α-amine of the N-terminal tyrosine and adds C6H8O to the chain's formula. That addition is about 96.06 Da.

Forty-four, all coded amino acids, carrying the sequence of GHRH(1–44). The only non-peptide part is the trans-3-hexenoyl cap on the N-terminal tyrosine. With no cysteine in the chain, there is no disulfide bridge, and its single methionine is the one sulfur-containing residue.

5135.9 g/mol for the formula C221H366N72O67S. At this mass electrospray LC-MS shows a series of multiply charged ions, which are deconvoluted to one neutral mass for comparison with the calculated value.

218949-48-5, with the molecular formula C221H366N72O67S and a molecular weight of 5135.9 g/mol. PubChem lists the compound as CID 16137828. The single sulfur atom in the formula is the chain's one methionine.

No. The chain has no cysteine, so it stays a single linear peptide. Its one sulfur atom belongs to a methionine residue.

The oxidised form of the chain's single methionine, one oxygen atom and 16 Da heavier than the parent peptide. It is the typical related substance looked for in HPLC and confirmed by its mass.

C221H366N72O67S. It counts the forty-four-residue chain together with the trans-3-hexenoyl cap, and its single sulfur atom belongs to the chain's one methionine.

Order Tesamorelin directly from British Peptide Labs, a UK-registered company. It is supplied in a sealed 10 mg vial at £85.00 (£8.50 per mg). Every vial is ≥99% purity (HPLC), with independent third-party testing by PeptideVerify. Orders placed before 3pm Mon–Sat leave the same day by Royal Mail Tracked 24 for next-day tracked delivery.

Tesamorelin comes in one sealed vial: 10 mg at £85.00 (£8.50 per mg). Delivery is free on every order.

Tesamorelin is catalogued in the GHRH, GHS-R & IGF-1 Analogues research area, where compounds are grouped by molecular class. The research area page lists each of them with its identifiers.

GHRH, GHS-R & IGF-1 Analogues research area

Tesamorelin has independent third-party testing by PeptideVerify: reversed-phase HPLC measures purity, at ≥99% (HPLC), and LC-MS confirms identity against the expected mass.

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