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GHRH, GHS-R & IGF-1 Analogues

Ipamorelin

Ipamorelin is a synthetic pentapeptide. Supplied as a lyophilised powder in a sealed vial for laboratory research. Available in a 10 mg presentation.

In stock
10 mg vial£55.00

£5.50 per mg

≥99% purity (HPLC) · Independent third-party testing by PeptideVerify · COA Library

Order before 3pm for same-day dispatch.

Cut-off 3pm, Mon–Sat

Free next-day tracked delivery on every order · Royal Mail Tracked 24

10 mg · £55.00 · £5.50/mg

At a glance

Research area
GHRH, GHS-R & IGF-1 Analogues · Explore the research area
Presentations
10 mg
Form
Lyophilised powder in a sealed vial
Purity
≥99% (HPLC)
CAS number
170851-70-4
Molecular formula
C38H49N9O5
Molecular weight
711.85 g/mol
Residues
5
Monoisotopic mass
711.3857 Da
Dispatch
Order by 3pm Mon–Sat for same-day dispatch

About Ipamorelin

Ipamorelin is a synthetic pentapeptide, H-Aib-His-D-2-Nal-D-Phe-Lys-NH2, and a GHS-R1a ligand. Three of its five residues are non-standard. Aib (α-aminoisobutyric acid) has two methyl groups on its α-carbon and no stereocentre; D-2-Nal is 3-(2-naphthyl)-D-alanine, which carries a naphthalene ring; and D-Phe is the D-enantiomer of phenylalanine. The C-terminal lysine ends in an amide.

The catalogue lists CAS number 170851-70-4, the molecular formula C38H49N9O5 and a molecular weight of 711.85 g/mol. The naphthyl and phenyl rings absorb strongly in the ultraviolet, which suits HPLC detection. A diastereomer with an L-residue in place of a D-residue has exactly the same mass, so chromatography rather than mass spectrometry is what separates the two. Each presentation is supplied as a lyophilised powder in a sealed vial.

Identifiers

Further reading

Ipamorelin structure and analytical profile

The five residues are Aib1, His2, D-2-Nal3, D-Phe4 and Lys5, written compactly as [Aib]H[D-2-Nal]fK-NH2. Only histidine and lysine are coded L-amino acids. Aib, α-aminoisobutyric acid, is achiral because its α-carbon carries two identical methyl groups. D-2-Nal, 3-(2-naphthyl)-D-alanine, is an alanine bearing a naphthalene ring, and D-Phe is the mirror-image form of phenylalanine.

Two D-centres sit side by side, at positions 3 and 4. Swapping either for its L-form gives a diastereomer of identical formula and mass, so the stereochemistry is checked by HPLC retention, or by chiral amino acid analysis after hydrolysis, rather than by mass spectrometry.

Histidine at position 2 is the chain's only residue with an imidazole ring and lysine at position 5 its only side-chain amine; with the N-terminal amine of Aib they are the three sites that take up protons in electrospray.

The N-terminal Aib keeps a free amine, and the C-terminal lysine ends in an amide, -NH2, so the chain has no free carboxylic acid. Its basic groups are the N-terminal amine, the lysine side-chain amine and the histidine imidazole, with no acidic side chain to balance them.

The calculated net charge near pH 7 is about +2.2, which makes ipamorelin strongly cationic. The naphthyl ring of D-2-Nal and the phenyl ring of D-Phe are large, flat aromatic groups that give the short chain both hydrophobic retention in reversed-phase HPLC and a strong ultraviolet signal.

The monoisotopic mass is 711.3857 Da, so the [M+H]+ ion is expected at m/z 712.3929 and the [M+2H]2+ ion at m/z 356.7001. The formula C38H49N9O5 and the average molecular weight of 711.85 g/mol refer to the free peptide; a salt form weighs more per mole without changing the peptide's own mass.

Because Aib has no α-hydrogen it cannot epimerise during synthesis, so the stereochemical checks concentrate on the two D-residues and on the L-histidine and L-lysine.

Reversed-phase HPLC, read where the naphthalene ring absorbs or around 214 nm, gives purity as the main peak's share of total peak area and resolves the D/L diastereomers that mass spectrometry cannot. The material is a white to off-white lyophilised solid in a sealed vial. The sealed vial is stored at 2–8 °C short term, or at −20 °C and below for long-term storage, protected from light and away from repeated freeze-thaw cycles.

Buying Ipamorelin in the UK

Order Ipamorelin directly from British Peptide Labs, a UK-registered company, as a sealed vial in 10 mg presentation, from £55. Every size is listed below with its vial price and its price per mg, so the presentations compare at a glance.

Ipamorelin price (UK)
PresentationPrice£/mg
Ipamorelin 10 mg£55.00£5.50

Choose a presentation in the buy box, add it to your basket and check out. Orders placed before 3pm Mon–Sat are packed the same working day and handed to Royal Mail Tracked 24, and your tracking number is emailed as soon as the parcel leaves us. Larger orders are welcome: add as many vials as your laboratory needs in a single basket.

For what other UK suppliers charge, see our UK price per mg data, updated every month.

Product information

CAS number
170851-70-4
Molecular formula
C38H49N9O5
Molecular weight
711.85 g/mol
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH2
Appearance
White to off-white lyophilised powder
Purity
≥99% (HPLC)
Net content
10 mg per vial
Storage (sealed vial)
Store at 2–8 °C short term, or at −20 °C and below for long-term storage. Protect from light and avoid repeated freeze-thaw cycles
Residues
5
One-letter sequence
[Aib]H[D-2-Nal]fK-NH2
Monoisotopic mass
711.3857 Da
Expected [M+H]+
m/z 712.3929
Net charge near pH 7
+2.2
PubChem CID
9831659
Research use
For laboratory research use only. Not for human or veterinary use.

Ipamorelin is a synthetic pentapeptide. Supplied as a lyophilised powder in a sealed vial for laboratory research. Available in a 10 mg presentation. Store the sealed vial at 2–8 °C for short-term storage, or at −20 °C and below for long term. Protect from light and avoid repeated freeze-thaw cycles. For research use only. Not for human or veterinary use. Sold strictly for in-vitro laboratory research; not for diagnosis or treatment.

Packing
Each sealed vial travels in protective packing.
Dispatch
Orders placed before 3pm Mon–Sat leave the same day.
Delivery
Next-day tracked delivery with Royal Mail Tracked 24.
Tracking
Your tracking number is emailed as soon as the order is dispatched.
Delivery cost
Delivery is free on every order.
Shipping details

Questions about Ipamorelin

Ipamorelin is a synthetic pentapeptide. It is supplied in a sealed vial as a white to off-white lyophilised powder, in a 10 mg presentation.

Read the Learn article

711.3857 Da, calculated from the formula C38H49N9O5. The [M+H]+ ion is expected at m/z 712.3929 and the [M+2H]2+ ion at m/z 356.7001, against an average molecular weight of 711.85 g/mol. A salt form, such as an acetate, weighs more per mole but gives the same ions.

3-(2-naphthyl)-D-alanine: an alanine whose side chain carries a naphthalene ring, in the D-configuration. It sits at position 3 and gives the peptide much of its ultraviolet absorbance and hydrophobic character.

α-aminoisobutyric acid, the N-terminal residue. It has two methyl groups on its α-carbon, so it has no stereocentre, and it is not one of the twenty coded amino acids.

170851-70-4, the number CAS Common Chemistry records for this structure, with the molecular formula C38H49N9O5. PubChem lists the compound as CID 9831659.

About +2. The free N-terminal amine and the lysine side chain carry positive charges, the histidine adds a little more, and the amidated C-terminus and the absence of acidic side chains leave nothing negative to balance them.

Two: 3-(2-naphthyl)-alanine at position 3 and phenylalanine at position 4. Histidine and lysine are L-residues, and Aib has no stereocentre at all. An L-form at either position gives a diastereomer of identical mass, so HPLC retention, or chiral amino acid analysis after hydrolysis, confirms the configuration.

Its naphthalene and phenyl rings absorb ultraviolet light strongly, well beyond what a five-residue chain of coded aliphatic residues would give, so the main peak and its related substances are easy to quantify.

Order Ipamorelin directly from British Peptide Labs, a UK-registered company. It is supplied in a sealed 10 mg vial at £55.00 (£5.50 per mg). The 10 mg vial is in stock. Every vial is ≥99% purity (HPLC), with independent third-party testing by PeptideVerify. Orders placed before 3pm Mon–Sat leave the same day by Royal Mail Tracked 24 for next-day tracked delivery.

Ipamorelin comes in one sealed vial: 10 mg at £55.00 (£5.50 per mg). Delivery is free on every order.

Ipamorelin is catalogued in the GHRH, GHS-R & IGF-1 Analogues research area, where compounds are grouped by molecular class. The research area page lists each of them with its identifiers.

GHRH, GHS-R & IGF-1 Analogues research area

Ipamorelin has independent third-party testing by PeptideVerify: reversed-phase HPLC measures purity, at ≥99% (HPLC), and LC-MS confirms identity against the expected mass.

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